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Long-term follow-up supports sustained benefit: 84% of initial responders maintained improvement at 1 year without side effects (Rucklidge et al., 2017), and a 1.5 to 5 year observational study found continued improvement in scores for ADHD, mood, and anxiety, with scores in the “normal,” non-clinical range (Rucklidge et al., 2019)

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For a 12-week protocol , estimated use increases to approximately 58.8 mg , requiring 6 vials